CBD and Endocannabinoid System: What are The Relation Between Them?

CBD is a product that has gained popularity in recent years. It is produced through some industrial processes that require care and state-of-the-art facilities. Several reasons are responsible for some doubts and questions about using or consuming CBD and CBD infused products. The product associates with several benefits and directly affects the endocannabinoid system of humans or similar systems in animals, which is the main reason for its use and importance. For more info about CBD and endocannabinoid system and how it can affect your bodily functions, do continue reading this article. Hopefully, you will gain enough knowledge to clear out those doubts.

The Origin of CBD

Let us first consider the question, what is CBD? 

CBD is a short form of cannabidiol, a compound found majorly in the cannabis plant’s leaf. It is one of the many cannabinoids present in the plant, along with THC and many others. However, it has been found to provide some health benefits and is consumed for this reason. Although it was previously illegal and currently, there are limited studies on its benefits and dangers. 

The FDA has warned manufacturers not to, in any case, advertise the product as a drug to cure, heal, or treat any condition. Nevertheless, the use of the product is widespread.

What is an Endocannabinoid System? 

The body is made of several complexes and systems that work together to bring about movements and living. One of these systems is the endocannabinoid system. This is the system that determines the effect of the state that we call “High.”

The endocannabinoid system comprises two main receptors found in body cells; they are CB1 and CB2 receptors. While the CB1 is commonly found in the brain and nervous system, the CB2 is located in other body organs. CB1 functions with hormones and operations that involve movement, stress, pain, and memory. 

CB2 in the body organs is responsible for another immune, cardiovascular, and muscular function. Endocannabinoids are synthesized by the body and act as neurotransmitters to stimulate body functions. 

The Endocannabinoid system controls mood, sleep, homeostasis, heart function, pain, and body metabolism.


Effects of CBD On the Endocannabinoid System

The Endocannabinoid system is known to exert an effect generally on the body through its important receptors. These receptors include CB1 and CB2, while THC reacts directly, and preferably with CB1 receptors, CBD does not. It does not directly interact with these receptors. 

Therefore, since cannabidiol does not act directly on these receptors, its use does not stimulate brain activities. Once the brain activity is not stimulated, no psychoactive effect will be produced. Rather than conclude that it is not psychoactive, it is preferable to say that it is not intoxicating. Hence, users will not get high. Using cannabidiol does not affect the mind or stability of users and can rather prove beneficial. 

However, in processes where topnotch and cutting-edge equipment is used, to obtain 0% THC in products is not possible. While this compound can be reduced to minimal, no method can completely remove it from the product. 

Therefore, noticing THC in your CBD oil is possible since total removal is not possible. Nevertheless, it is advisable to get a reputable manufacturer with enough equipment to reduce to minimal THC content.

Only CBD cannot get you high, but it may get you high because it is completely inseparable from THC. Therefore, getting your CBD products from a reputable manufacturer is very important. 

How THC & CBD Affect the Endocannabinoid System

THC and CBD are known to produce effects when taken. CBD oil and creams are products that are usually taken for pain and disorders. THC supplemented creams are also used for this purpose.

THC works by binding to receptors known as CB1 and CB2 in the body. Although it is usually attached, preferably to CB1, this fusion activates the endocannabinoid system. Activation of the cannabinoid system releases signals that affect the nervous system and cause body changes. 

Cannabidiol works differently from THC. It does not bind to the CB1 or CB2 receptors, as observed in THC. Instead, it inhibits the binding of enzymes in the body, causing the THC to lose its binding site. This binding produces changes; these changes may include emotions, pain relief, and many other significant effects. 

The Differences Between Both of Them

CBD and THC are two cannabinoids that are often misinterpreted. Since both of them are one of the cannabinoids found in the cannabis plant. Here’s a short comparison of CBD vs. THC 

However, though they are similar, they are very different and produce different effects on users. THC, short for tetrahydrocannabinol, is a hydroxyl modification of the structural CBD. It causes the psychoactive effect on marijuana. This effect is one of the reasons CBD products were formerly illegal. 

CBD, on the other hand, is the acronym for cannabidiol. It is present in various forms like oils, creams, and many others. Unlike THC, it does not produce any observable psychoactive effect and will not get users high. 

Psychoactive Effects: How and Which Causes it in The ECS?

Certain conditions and information about CBD make people think that the product is psychoactive. For more on this question, read on. 

You may have heard your colleague or friend about to start as a user question that does CBD get you high? The reason for this is because CBD is from a family of cannabinoids. These compounds are found in the hemp and cannabis plants.

You would have heard of cannabis in marijuana, and this similarity cannot just be in the name, right? However, this assumption is not true; although CBD is from the same plant, it does not get you high. CBD is just one of the hundreds of compounds present in the plant. CBD doesn’t affect the known receptor that causes a psychoactive effect in the ECS; thus, CBD and Endocannabinoid system remain neutral in the case of getting high.

We all know that the ECS consists of cannabinoid receptors. Over the past 10 years, scientists’ primary interest has been on CB1Rs for their role across many physiological functions. And one of those functions is the psychoactive effect of delta9-tetrahydrocannabinol, which in short we know as THC, which is found in cannabis. 

The CB1Rs are vastly found G-protein-coupled receptors in the central nervous system of the human body. THC actually affects the CB1Rs receptor of the endocannabinoid system and causes the psychoactive effects as we know of.

Can You Fail A Drug Test for Using CBD? 

Are you one of those people that need to pass drug tests in your place of work? And you are wondering that does CBD show on a drug test? Well! I have the answer to your question.

You are possibly only planning to obtain CBD creams for pain or sleep disorders and worry if it may fail your drug test. 

Three distinct types of these products are available commercially. The most common is the isolate creams, containing only cannabidiol as its active ingredient. The broad spectrum contains other cannabinoids, and the full-spectrum contains a portion of Tetrahydrocannabinol, which causes the psychoactive effect as we briefly discussed above, THC, CBD, and endocannabinoid system.

As an individual that may have to take drug tests, it is advised that you do not take full-spectrum products. Although they may not fail your test, it is best to be safer. The broad spectrum and isolate products do not contain a detectable amount of THC and will not fail your drug test. 


Normally, some people may assume that CBD can get users stoned. However, as CBD and endocannabinoid systems don’t have that relation, this assumption is untrue and should not be adopted. Cannabidiol does not produce any intoxicative or sedative effect, and you are safe when using the product. However, the process of extraction of this compound is very sensitive. Therefore, ensure that you buy only from reputable manufacturers. 

You can start your CBD journey without fear of waking up disordered or abnormally. Moreover, it is available in several forms to suit your taste and needs.

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